Posts Tagged ‘AMH – Anti-Müllerian hormone’

What is AMH?

Thursday, May 7th, 2009

Good article explaining the basics of AMH:

Anti-Müllerian Hormone (AMH)
Müllerian Inhibiting Substance (MIS)

If I have an AMH of 0.6 and FSH of 5.5, stage 3 endo removed in AUgust last year and 30 years old, would IVF be my only option? We’ve been doing IUI with donor sperm (due to DH having azoospermia)but we have been unlucky 8 times

Monday, May 4th, 2009

With an AMH of 0.6, a history of stage 3 endometriosis and failed inseminations with good quality donor sperm, IVF is without a doubt the next step sooner rather than later.

- Answers kindly provided by Dr. Stephan Volschenk -

I know it might be a million-dollar question, but aside from maintaining a moderately healthy lifestyle, is there anything women can do outside the “lab” or fertility clinic to improve their chances of conception? I’ve read of women who get different AMH results from one test to another, and in some cases an increase? What would account for these differences?

Friday, January 30th, 2009

The issue with the AMH is not the fluctuation, but the cut off value as far as response and prognosis goes. Like FSH levels, AMH levels fluctuate as well, but to a much lesser extent, hence the better predictive value. Therefore, apart from trying to maintain a healthy lifestyle, not smoking or drinking and trying to stick to a balanced diet, from an evidence based point of view there is not too much else that can be done to change the outcome.

- Bi-Week 30 answers kindly provided by Dr. Stephan Volschenk -

What is the success rate of IVF with own eggs with an AMH of between 0.5 and 1 at the age of 25 if there are no male factor problems?

Wednesday, January 14th, 2009

The success rate is less than that of somebody with a normal AMH at age 25. This is due to the anticipated poor response to stimulation of the ovaries, leading to less eggs harvested. However, the issue is that even though one may harvest fewer eggs, the eggs being harvested are still only 25 years old which is the silver lining, so to speak. Therefore at age 25, one should still be optimistic about having a good outcome.

- Week 29 answers kindly provided by Dr. Stephan Volschenk -

What exactly does a very high AMH mean? What causes low AMH and can it be prevented?

Sunday, November 9th, 2008

AMH is an indicator of egg quantity and indirectly, possible egg quality. A very high AMH is more likely than not an indication of underlying PCOS. A low AMH is an indicator of diminished ovarian reserve volume and can not be prevented as one can not stop one’s biological clock. It is important to remember that AMH is just one of a few tools in order to establish ovarian reserve volume and should be interpreted in conjunction with all the other tools available.

- Week 22 answers kindly provided by Dr. Stephan Volschenk -

Can a person with a low AMH display a high count of antral follicles on ultrasound?

Friday, June 13th, 2008

This is possible when there is an error in running the test, in other words a technicality from the lab. That is exactly the reason why one ALWAYS has to correlate the result with what you see on ultrasound. ( Almost as a backup safety net so to speak). The golden rule is to correlate and if still not satisfied, to repeat the test. The AMH test is very temperature sensitive and therefore a break in this temperature chain may lead to an inappropriate result.

- Week 16 answers kindly provided by Dr. Stephan Volschenk -

If an AMH hormone test indicated a very low value (indicating very low ovarian reserve and function) – will this mean that the value will decrease even more over time, or can this hormone also fluctuate ? Should one be tested for AMH also over a period in time to see if the count remains the same?

Wednesday, March 26th, 2008

The fluctuation of AMH is minimal and not enough to significantly influence or change a prognosis. It will decline over time as the ovarian reserve runs out towards menopause. If the level is significantly low to start out with, repeating the level does not make sense as the ultimate outcome will not change.

- Week 7 answers kindly provided by Dr. Stephan Volschenk -

Every woman in infertility treatment eventually gets tested for: 17B Oestriadol, FSH, LH, Prolactin, AMH Very little information is available on these results, especially from South African sources. We understand that values can differ from lab to lab, but could you possibly give us reference values according to your own lab(Lancet – Vitalab) to help us understand our results better?

Wednesday, March 26th, 2008

The reference range of the mentioned tests do differ from lab to lab, depending on the assays used and units used to express the findings. When looking at results, one therefore has to see the complete picture. Hormone profiles, from an infertility point of view , only have meaning when done on day 2 or 3 of the menstrual cycle. Outside of this window period, the results have no significance at all. From that point of view the following is of significance:

1) 17B Oestradiol – Less than 200
2) FSH – Less than 10
3) LH – Less than 10
4) Prolactin and thyroid within the normal range of the laboratory used
5) In our clinic AMH levels of 1.1 and above would be in keeping with a fair to good chance

- Week 5 answers kindly provided by Dr. Stephan Volschenk -


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